Lalcolismo di Tatyana Samoylova

TUTTO QUELLO CHE DEVI SAPERE SULL'ALCOL: #TELOSPIEGO!

Codificazione di rinascita di alcolismo

Tatiana I. Phage display is a powerful technique for identifying peptides or proteins that specifically recognize and bind to particular molecular targets. For more than Lalcolismo di Tatyana Samoylova years, she has been applying phage display as a discovery tool for development of highly specific peptide-based diagnostic and therapeutic agents for numerous applications in human and veterinary medicine including cell targeting in genetic diseases, cancer and immunocontraception.

Over the years, development of contraceptive vaccines for control of wild and feral animal populations has become Dr. Immunocontraception is a promising strategy for animal population control. The focus of Dr. These antibodies interfere with male and female reproductive functions, leading to Lalcolismo di Tatyana Samoylova in fertility. Examples of antigens used in Dr. One of Dr. A single dose, non-surgical sterilant Lalcolismo di Tatyana Samoylova could be administered in the field at a reasonable cost would be an ideal solution, and would save lives and end suffering for millions of companion animals throughout the world.

The goal is to create a vaccine that will fulfill these requirements. The vaccine is designed to include phage particles carrying multiple copies of gonadotropin releasing hormone Lalcolismo di Tatyana Samoylova peptides. Animals respond to such vaccines by producing anti-GnRH antibodies, which are known to affect fertility, reducing or preventing pregnancies. Other uses of such GnRH-based vaccines may be in the treatment of human and animal hormone-dependent reproductive cancers.

Development of contraceptive vaccines for wild pigs is another major area of Dr. Populations of wild pigs are rapidly expanding throughout the United States, causing annual losses of up to several billion dollars in damages to agriculture and other areas of the economy.

Current control programs that focus on wild pig eradication through trapping and hunting are expensive, inefficient, and unacceptable for Lalcolismo di Tatyana Samoylova of the public. Unlike any other contraceptive for wildlife, Dr. Species specificity is one of the major requirements for an ideal contraceptive for wildlife since such vaccines need to be distributed in uncontrolled environments where they could contact non-target species, resulting in unwanted loss of fertility in the non-target animals.

The approach is unique and protected by two issued U. Potentially, it can be applied to population control of multiple wildlife species. This project is a part of a larger initiative by Auburn University that includes researchers from the College of Veterinary Medicine as well as School of Forestry and Wildlife.

All rights reserved. Auburn, Alabama Phone: Research Interests: Dr. Phage constructs targeting gonadotropin releasing hormone for fertility control: evaluation in cats.

Journal of Feline Medicine and Surgery, accepted. DNA vaccine targeting gonadotropin-releasing hormone receptor and its application in animal contraception.

Mol Biotechnol. Immunocontraception: filamentous bacteriophage as a platform for vaccine development. Current Medicinal Chemistry, Immunocontraception as a tool for population control of wild pigs.

Alabama Wildlife,80 4 Infective and inactivated filamentous phage as carriers for immunogenic peptides. J Virol Methods,1 Generation and characterization of phage-GnRH chemical conjugates for potential use in cat and dog immunocontraception. Reproduction in Domestic Animals,47 Suppl. Phage display allows identification of zona pellucida-binding peptides with species-specific properties: novel approach for development of contraceptive vaccines for wildlife.

J Biotechnology, ZP-binding peptides identified via phage display stimulate production of anti-sperm antibodies in dogs. Anim Reprod Sci, Phage display in Lalcolismo di Tatyana Samoylova tumor Lalcolismo di Tatyana Samoylova. Phage display for generating peptide reagents. Unit In: Current Protocols in Protein Science book chapter. Metabolic Brain Disease,23 2 Designing allosteric peptide ligands targeting a globular protein.

Biopolymers, Lalcolismo di Tatyana Samoylova, 85 1 Peptide phage display: opportunities for development of personalized anti-cancer strategies. Anti-Cancer Agents — Medicinal Chemistry,6 1 Novel metal clusters isolated from blood are lethal to cancer cells. Cell targeted phagemid rescued by pre-selected landscape phage. Gene, Phage matrix for isolation of glioma cell-membrane proteins. BioTechniques,37 2 Phage probes for malignant glial cells.

Molecular Cancer Therapeutics, Molecular markers of glial tumors: current targeting strategies. Identification of cell targeting ligands using random peptide-presenting phage libraries. In: Genetic Library Construction and Screening.

Advanced Techniques and Applications. Recognition of cell-specific binding of phage display derived peptides using an acoustic wave sensor. Biomolecular Engineering, Lalcolismo di Tatyana Samoylova biosensor for recognition of cross-species cell surface markers. J Molecular Recognition, Targeting peptides for microglia identified via phage display. J NeuroImmunology, Phage constructs, sequences and antigenic compositions for immunocontraception of animals.

Patent No. Zona pellucida binding peptides for species-specific immunocontraception of animals. Methods of identifying peptides and compositions that bind to oocytes in a species-specific manner. Methods for identifying peptides that bind to intact oocytes.

Methods for targeting and killing glioma cells. Ligand sensor devices and uses thereof. Peptides for recognition and targeting of glial cell tumors. Methods and compositions for targeting compounds to the central Lalcolismo di Tatyana Samoylova system. Methods and compositions for targeting compounds to muscle. Clinical Sciences Pathobiology.